



|
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【姓 名】吳彰哲
(Chang-Jer Wu, Ph. D.)
【職
稱】教授
(Professor)
【學
歷】國防醫學院博士
(National Defense Medical Center)
【專
長】分子生物學、病毒學、免疫學、生物技術學
(Molecular Biology, Virology, Immunology, Biotechnology)
【聯絡電話】(02)2462-2192
# 5137
【電子信箱】cjwu@mail.ntou.edu.tw
【教授課程】食品生物技術、生物化學、微生物學、應用微生物學、免疫學、生物工程概論、高等食品生物技術
【研究方向】
1.
新一代疫苗技術-基因疫苗的建立與開發
2.
機能性食品輔助新興傳染病預防及治療之研究
3.
抗病毒藥物篩選及機制之研究
4.
抗癌藥物篩選及機制之研究
【近年研究計畫】
|
年別 |
計劃名稱 |
單位 |
|
98 |
開發抗登革病毒與腸病毒71型的藥物及疫苗之快速篩選平台--抗登革病毒及腸病毒71型的藥物及疫苗之研發(總計畫及子計畫一)(1/3) |
國科會 |
|
98 |
抗幽門螺旋桿菌(Helicobacter pylori)感染之DNA疫苗及口服疫苗之研發(1/3) |
國科會 |
|
96 |
兒茶素(EGCG)抑制laminin受器媒介的癌細胞轉移及調節癌細胞GM-CSF訊息傳遞之研究 |
國科會 |
|
95 |
研發疫苗新佐劑配方加強日本腦炎DNA疫苗之免疫活性(II) |
農委會 |
|
95 |
兒茶素(EGCG)抑制日本腦炎病毒感染之研究 |
國科會 |
|
95 |
日本腦炎DNA疫苗新的傳輸策略--皮膚滲透免疫法(2/2) |
國科會 |
|
94 |
日本腦炎DNA疫苗新的傳輸策略--皮膚滲透免疫法(1/2)
|
國科會 |
|
94 |
日本腦炎DNA疫苗在豬隻之效能研發 |
國科會 |
|
93 |
研發疫苗新佐劑配方加強日本腦炎DNA疫苗之免疫活性(I) |
國科會 |
|
93 |
高效能的日本腦炎DNA疫苗之研發(II) |
農委會 |
|
92 |
利用日本腦炎DNA疫苗做為基因槍效能之研發 |
國科會 |
|
92 |
利用siRNA抑制嚴重急性呼吸道症候群(SARS)冠狀病毒複製研究 |
國科會 |
|
92 |
利用siRNA相關技術研發抑制日本腦炎病毒複製之新藥 |
國科會 |
|
91 |
高效能的日本腦炎DNA疫苗之研發(I) |
國科會 |
|
91 |
利用CpG
motif做為日本腦炎DNA疫苗佐劑之研發 |
國科會 |
【著作目錄】
發表之論文:
|
年別 |
題目 |
|
2010 |
Chai, H. J.,
J. H. Li, H. N. Huang, T. L. Li, Y. L. Chan, C. Y. Shiau and C. J. Wu.
Effects of sizes and conformations of
fish scale
collagen peptides (FSCPs)
on facial skin qualities and transdermal penetration efficiency.
Journal of Biomedicine and Biotechnology. |
|
2010 |
吳彰哲,黃瀚寧. 蝦蟹殼中的寶貝-幾丁質.
科學發展月刊.
第448期, 12-19. |
|
2010 |
Chuang, K. H.,
S. C. Tzou, T. C. Cheng, C. H. Kao, W. L. Tseng, J. Shiea, K. W. Liao,
Y. M. Wang, Y. C. Chang, B. J. Huang, C. J. Wu, P. Y. Chu, S. R.
Roffler and T. L. Cheng. Measurement of poly(ethylene glycol) by
cell-based anti-poly(ethylene glycol) ELISA. Anal Chem.,
82:2355-2362. |
|
2010 |
Lin, C. S., P.
J. He, N. M. Tsai, C. H. Li, S. C. Yang, W. T. Hsu, M. S. Wu, C. J.
Wu, T. L. Cheng and K. W. Liao. A potential role for Helicobacter
pylori heat shock protein 60 in gastric tumorigenesis. Biochem
Biophys Res Commun., 392:183-189. |
|
2009 |
Chang, L. P.,
Y. S. Lai, C. J Wu and T. C. Chou.
Liquid
perfluorochemical inhibits inducible nitric oxide synthase expression
and nitric oxide formation in lipopolysaccharide-treated RAW 264.7
macrophages.
Journal of
Pharmaceutical Sciences.,
111:147-154. |
|
2009 |
Huang, Y. T.,
S. Y. Lyu, P. H. Chuang, N. S. Hsu, Y. S. Li, H. C. Chan, C. J. Huang,
Y. C. Liu, C. J. Wu, W. B. Yang and T. L. Li. In vitro
Characterization of Enzymes Involved in the Synthesis of
Nonproteinogenic Residue (2S, 3S)-beta-Methylphenylalanine in
Glycopeptide Antibiotic Mannopeptimycin.
Chembiochem., 10:2480-2487. |
|
2009 |
Huang, H.
N., T.
L. Li, Y. L. Chan, C. L. Chen and C. J. Wu.
Transdermal immunization with low-pressure-gene-gun mediated chitosan-based
DNA vaccines against Japanese encephalitis virus. Biomaterials.,
30:6017-6025. |
|
2009 |
Yang, S.
W., Y. S. Lee, T. A. Chen, C. J. Wu, and C. N. Tsai. Human
papillomavirus in oral leukoplakia is no prognostic indicator of
malignant transformation.
Cancer Epidemiology., 33: 118-122. |
|
2009 |
Cheng, J.
Y., H. N. Huang,
W. C. Tseng,
T. L. Li,
Y. L.
Chan,
K. C. Cheng
and C. J. Wu. Transcutaneous immunization by lipoplex-patch based
DNA vaccines is effective vaccination against Japanese encephalitis
virus infection. Journal of Controlled Release., 135:242-249. |
|
2007 |
Li, Y. S.,
J. Y. Ho, C. C. Huang, S. Y. Lyu, C. Y. Lee, Y. T. Huang, C. J. Wu,
H. C. Chan, C. J. Huang, N. S. Hsu, M. D. Tsai and T. L. Li.
A unique
flavin mononucleotide-linked primary alcohol oxidase for glycopeptide
A40926 maturation. Journal of the American Chemical Society.,
129:13384-13385.
(SCI) |
|
2006 |
Ho, J. Y., Y.
T. Huang, C. J. Wu, Y. S. Li, M. D. Tsai and T. L. Li, 2006,
Glycopeptide biosynthesis: Dbv21/Orf2* from dbv/tcp gene
clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and
Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase.
Journal of the American Chemical Society., 128:13694-13695.
(SCI) |
|
2006 |
Wu, C. J.,
T. L. Li, H. W. Huang, M. H. Tao and Y. L. Chan, 2006, Development of an
effective Japanese encephalitis virus-specific DNA vaccine. Microbes
and Infection., 8:2578-2586.
(SCI) |
|
2006 |
Wu, C. J.
and Y. L. Chan, 2006, Antiviral applications of RNAi for coronavirus.
Expert Opin. Investig. Drugs., 15:89-97.
(SCI) |
|
2005 |
Chaung, H.
C., Y. Z. Chen, W. B. Chung, C. J. Wu, 2005, Generation and
characterization of dendritic cells derived from swine bone marrow
haematopoietic cells in vitro. Taiwan Veterinary Journal.,
31:195-207. |
|
2005 |
Wu, C. J.,
H. W. Huang, C. Y. Liu, C. F. Hong and Y. L. Chan, 2005, Inhibition of
SARS-CoV replication by siRNA. Antiviral Research., 65:45-48.
(SCI) |
|
2004 |
Wu, C. J.,
J. T. Jan, C. M. Chen, H. P. Hsieh, Y. S. Chao, H. W Liu, C. Y. Liu, H.
W. Huang, S. C. Chen, C. F. Hong, R. K. Lin, D. R Hwang and J. T. A.
Hsu, 2004, Inhibition of SARS-CoV replication by niclosamide,
Antimicrobial Agents and Chemotherapy., 48:2693-2696. (SCI)
|
|
2004 |
Wu, C. J.,
S. C. Lee, H. W. Huang and M. H. Tao, 2004, In vivo
electroporation of skeletal muscle increases the efficacy of Japanese
encephalitis virus DNA vaccine, Vaccine., 22:1457-1464. (SCI)
|
|
2003 |
Chou, T.
C., E. Fu, C. J. Wu, J. H. Yeh, 2003, Chitosan enhances platelet
adhesion and aggregation, Biochem Biophy Res Comm., 302:480-483.
(SCI) |
|
2003 |
Hsieh Y.
H., C. J. Wu, K. P. Chow, C. L. Tsai, and Y. S. Chang, 2003,
Electroporation-mediated and EBV LMP1-regulated gene therapy in a
syngenic mouse tumor model, Cancer Gene Ther., 10:626-636. (SCI)
|
|
2003 |
Lee, S. C.,
C. J. Wu, P. Y. Wu, Y. L. Huang, C. W. Wu and M. H. Tao, 2003,
Inhibition of established subcutaneous and metastatic murine tumors by
intramuscular electroporation of the interleukin 12 gene, J Biomed
Sci., 10:73-86. (SCI) |
|
2003 |
Wu, C. J.,
H. W. Huang and M. H. Tao, 2003, Induction of cross-protection against
two wild-type Taiwanese isolates of Japanese encephalitis virus using
Beijing-1 strain DNA vaccine, Vaccine., 21:3938-3945. (SCI)
|
|
2001 |
吳彰哲,
2001, 21世紀的癌症新療法-樹突狀細胞(Dendritic
cell)免疫療法, 食品工業,
第33卷, 第8期:
21-26. |
|
2000 |
吳彰哲,
2000, 鼻咽癌(Nasopharyngeal
Carcinoma): Epstein-Barr病毒致病機制和治療策略之簡介,
中化藥訊, 第46期,
12-19. |
|
1998 |
Wu, C. J.,
C. Y. Leu, S. T. Liu, K. P. Chiu, C. L. Meng and Y. S. Chang, 1998,
Transcriptional activation of NF-B activity by Epstein-Barr virus (EBV)
LMP1 as a selective therapeutic strategy for EBV-associated diseases,
Gene Therapy, 5:905-912. (SCI) |
|
1997 |
Wu, C. J.,
K. S. S. Chang and Y. S. Chang, 1997, Transfer of the E6 and E7 genes of
human papillomavirus type 18 into human epithelial cells via recombinant
retrovirus infection, J Microbiol Immunol Infect., 30:123-134.
|
|
1997 |
Yeh, T. S.,
S. N. Li, C. J. Wu, S. T. Liu, C. L. Meng and Y. S. Chang, 1997,
Sequence variations between two Epstein-Barr virus LMP1 variants have no
effect on activation of NF-kB activity, DNA and Cell Biology.,
16:1311-1319. (SCI) |
專書著作:
|
年別 |
題目 |
|
2007 |
吳彰哲,
2007. 細胞培養與食品. 潘崇良編着,
食品生物技術.
華格那企業有限公司. |
|
2007 |
吳彰哲,
2007. 動物生物技術與食品. 潘崇良編着,
食品生物技術.
華格那企業有限公司. |
|
2006 |
Wu, C.
J. and Y. L. Chan.,
2006. Coronaviruses and severe acute respiratory syndrome associated
coronavirus (SARS-CoV). In: Hefferon, K.L. (Eds.), Recent advances in
RNA virus replication, first ed. Transworld research network, Kerala,
India, pp. 29-44. |
|
2006 |
吳彰哲編譯.
2006. 細胞與分子生物學. 合記圖書出版社. |
專利:
|
年別 |
題目 |
|
2008 |
吳彰哲,
陶秘華. 日本腦炎DNA疫苗.
中華民國發明專利, 發明第I302166號.
2008.10.21-2026.1.1. |
研討會發表之論文:
|
年別 |
題目 |
|
2009 |
Wu C. J.,
H. N. Huang, 2009,
Transcutaneous immunization by chitosan complex-patch
based DNA vaccines is effective vaccination against Japanese
encephalitis virus infection, The
3nd Global Congress on Vaccine,
Singapore. |
|
2009 |
Tsai, L. W.,
C. J. Wu, 2009,
The
polysaccharide extracts from Ulva lactuca
can inhibit the infection of enterovirus 71,
The 24th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2009 |
Tu, Y., C.
J. Wu, 2009, Epigalocatechin-3-gallate (EGCG) inhibit the growth and
metastasis of tumor through the signal transduction of 67-kDa laminin
receptor,
The 24th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2008 |
Wu C. J.,
H. N. Huang, 2008, Japanese encephalitis virus DNA vaccine using the
transcutaneous immunization by chitosan complexes, The 2nd
Global Congress on Vaccine,
Boston, USA. |
|
2008 |
Huang, H. N.,
C. J. Wu, 2008, Japanese encephalitis virus dna vaccine using the
transcutaneous immunization by chitosan complexes,
The 23th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2008 |
Yang, S. F.,
C. J. Wu, 2008, Study of the effects on the inhibition of
Japanese encephalitis virus infection in mice brain after
(-)-epigallocatechin gallate (EGCG) treatment,
The 23th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2008 |
Tung, H. M.,
C. J. Wu, 2008, Using three types of oral vaccines against
Helicobacter pylori infection,
The 23th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2007 |
Cheng, J. Y.,
H. N. Huang, K. C. Cheng, C. J. Wu, 2007, A new delivery strategy of
japanese encephalitis virus dna vaccine using the transcutaneous
immunization,
The 22th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2007 |
Chu, Y. H., H.
M. Tung, C. J. Wu, 2007, Using IgY to suppress the infection of
Vibrio Alginolyticus in small abalone,
The 22th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2007 |
Ciou, Y. H.,
C. J. Wu, 2007, Study of inhibitory effects of japanese encephalitis
virus infection by the extracts of taiwan algae,
The 22th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2007 |
Jhan, M. Y.,
S. F. Yang, S.Y. Liou, C. J. Wu, 2007, Study of inhibitory effects by
catechins in japanese encephalitis virus infection,
The 22th
Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2005 |
Ku, M. C.,
C. J. Wu, Y. N. Huang, S. F. Chi, J. Y. Wang, 2005, Vitamin D3
surpresses the production of proinflammatory cytokines and chemokines
production from glial cells in Japanese encephalitis virus infected
mice, The 20th Joint Annual Conferenceof Biomedical Sciences,
Taiwan. |
|
2005 |
Wu, C. J.,
H. W. Huang, C. Y. Liu, C. F. Hong, Y. L. Chan, 2005, Inhibition of
SARS-coronavirus replication by siRNA, The 20th Joint Annual
Conferenceof Biomedical Sciences, Taiwan. |
|
2005 |
Wu, C. J.,
H. W. Huang, Y. L. Chan, 2005, Construct a clinical used and high
efficient dna vaccine of Japanese encephalitis virus, The 20th Joint
Annual Conferenceof Biomedical Sciences, Taiwan. |
|
2005 |
Wu, Y. S.,
P. H. Lu, Y. C. Chao, J. T. Jan, C. J. Wu, C. M. Chen, J. P. Liou, H. R.
Lo, S. H. Ma, Y. S. Chao, T. A. Hsu, H. P. Hsieh, 2005, Promazine
Analogues as Potential Anti SARS-CoV Drugs. The 229th ACS National
Meeting, San Diego, California. |
|
2004 |
Chi, S. F.,
C. J. Wu, Y. N. Huang, J. Y. Wang, 2004, Japanese encephalitis virus
infects neurons and microglia in brain and spinal cord in mice, The
19th Joint Annual Conferenceof Biomedical Sciences, Taiwan. |
|
2003 |
Wu, C. J.,
M. F. Chang, M. H. Tao, H. W. Liu, S. R. Roffler, 2003, Aminopeptidase
N/ CD13 is not the SARS coronavirus receptor, International
conference on influenza and the resurgence of severe acute respiratory
syndrome (SARS), Taiwan. |
|
2003 |
Wu, C. J.,
Y. L. Chan, C. T. Yeh, S. C. Chen, Y. W. Hung and M. H. Tao, 2003,
Construct a clinical used and high efficient DNA vaccine of Japanese
encephalitis virus, The 15th European Immunology Congress
(EFIS 2003), Rhodes, Greece. |
|
2003 |
Wu, C. J.,
Y. L. Chan, H. W. Huang and M. H. Tao, 2003, In vivo electroporation of
skeletal muscle increases immunogenicity of JEV DNA vaccine without
cardiotoxin-pretreatment, The 15th European Immunology
Congress (EFIS 2003), Rhodes, Greece. |
|
2002 |
Wu, C. J.,
2002, Development of a highly efficient DNA vaccine for Japanese
encephalitis virus, The 29th National Defense Medical
Conference, Taiwan. |
|
2000 |
Wu, C. J.,
H. W. Huang and M. H. Tao, 2000, In vivo electroporation of skeletal
muscle increases immunogenicity of DNA vaccine, Australasian Society
of Immunology 30th Annual Conference, Australasian. |
|
1999 |
Wu, C. J.,
K. S. S. Chang and Y. S. Chang, 1999, Transfer of the E6 and E7 genes of
human papillomavirus type 18 into human epithelial cells via recombinant
retrovirus infection, Symposium of the 30th Annual Conference of
Microbiology and Immunology, Taiwan. |
|
1998 |
Wu, C. J.,
C. Y. Leu, S. T. Liu, K. P. Chiu, C. L. Meng and Y. S. Chang, 1998,
Transcriptional activation of NF-kB activity by Epstein-Barr virus (EBV)
LMP1 as a selective therapeutic strategy for EBV-associated diseases,
The 6th Symposium on Recent Advances in Cellular and Molecular Biology,
Taiwan. |
|
1996 |
Yeh, T. S.,
S. N. Li, C. J. Wu, S. T. Liu, C. L. Meng and Y. S. Chang, 1996,
Sequence variations between two Epstein-Barr virus LMP1 variants have no
effect on activation of NF-kB activity, The 7th Conference of the
International Association for Research on Epstein-Barr Virus and
Associated Diseases, Hong Kong. |
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